{"id":2047,"date":"2024-12-16T15:06:04","date_gmt":"2024-12-16T06:06:04","guid":{"rendered":"https:\/\/www.medikors.com\/eng\/?p=2047"},"modified":"2024-12-16T15:06:13","modified_gmt":"2024-12-16T06:06:13","slug":"pomegranate-extract-administration-reverses-loss-of-motorcoordination-and-prevents-oxidative-stress-in-cerebellum-ofaging-mice","status":"publish","type":"post","link":"https:\/\/www.medikors.com\/eng\/2024\/12\/16\/pomegranate-extract-administration-reverses-loss-of-motorcoordination-and-prevents-oxidative-stress-in-cerebellum-ofaging-mice\/","title":{"rendered":"Pomegranate Extract Administration Reverses Loss of MotorCoordination and Prevents Oxidative Stress in Cerebellum ofAging Mice"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"657\" height=\"932\" src=\"https:\/\/www.medikors.com\/eng\/wp-content\/uploads\/2024\/12\/image-6.png\" alt=\"\" class=\"wp-image-2048\" srcset=\"https:\/\/www.medikors.com\/eng\/wp-content\/uploads\/2024\/12\/image-6.png 657w, https:\/\/www.medikors.com\/eng\/wp-content\/uploads\/2024\/12\/image-6-211x300.png 211w\" sizes=\"(max-width: 657px) 100vw, 657px\" \/><\/figure>\n\n\n\n<p>Abstract: <\/p>\n\n\n\n<p>The cerebellum is responsible for complex motor functions, like maintaining balance and<br>stance, coordination of voluntary movements, motor learning, and cognitive tasks. During aging,<br>most of these functions deteriorate, which results in falls and accidents. The aim of this work was to<br>elucidate the effect of a standardized pomegranate extract during four months of supplementation<br>in elderly mice to prevent frailty and improve the oxidative state. Male C57Bl\/6J eighteen-monthold<br>mice were evaluated for frailty using the \u201cValencia Score\u201d at pre-supplementation and postsupplementation<br>periods. We analyzed lipid peroxidation in the cerebellum and brain cortex and the<br>glutathione redox status in peripheral blood. In addition, a set of aging-related genes in cerebellum<br>and apoptosis biomarkers was measured via real-time polymerase chain reaction (RT-PCR). Our<br>results showed that pomegranate extract supplementation improved the motor skills of C57Bl\/6J<br>aged mice in motor coordination, neuromuscular function, and monthly weight loss, but no changes<br>in grip strength and endurance were found. Furthermore, pomegranate extract reversed the increase<br>in malondialdehyde due to aging in the cerebellum and increased the reduced glutathione\/oxidized<br>glutathione (GSH\/GSSG) ratio in the blood. Finally, aging and apoptosis biomarkers improved in<br>aged mice supplemented with pomegranate extract in the cerebellum but not in the cerebral cortex.<\/p>\n\n\n\n<p>Body composition analyzer, small animal DXA, InAlyzer<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\"  class=\"wp-block-file__embed\" data=\"https:\/\/www.medikors.com\/eng\/wp-content\/uploads\/2024\/12\/2023_University-of-Valencia_Pomegranate-Extract-Administration-Reverses-Loss-of-Motor-Coordination-and-Prevents-Oxidative-Stress-in-Cerebellum-of-Aging-Mice.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of 2023_University of Valencia_Pomegranate Extract Administration Reverses Loss of Motor Coordination and Prevents Oxidative Stress in Cerebellum of Aging Mice.\"><\/object><a id=\"wp-block-file--media-4d5c1b61-c99f-4157-abd0-c99e7f91c9f0\" href=\"https:\/\/www.medikors.com\/eng\/wp-content\/uploads\/2024\/12\/2023_University-of-Valencia_Pomegranate-Extract-Administration-Reverses-Loss-of-Motor-Coordination-and-Prevents-Oxidative-Stress-in-Cerebellum-of-Aging-Mice.pdf\">2023_University of Valencia_Pomegranate Extract Administration Reverses Loss of Motor Coordination and Prevents Oxidative Stress in Cerebellum of Aging Mice<\/a><a href=\"https:\/\/www.medikors.com\/eng\/wp-content\/uploads\/2024\/12\/2023_University-of-Valencia_Pomegranate-Extract-Administration-Reverses-Loss-of-Motor-Coordination-and-Prevents-Oxidative-Stress-in-Cerebellum-of-Aging-Mice.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-4d5c1b61-c99f-4157-abd0-c99e7f91c9f0\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: The cerebellum is responsible for complex motor functions, like maintaining balance andstance, coordination of voluntary movements, motor learning, and cognitive tasks. During aging,most of these functions deteriorate, which results in falls and accidents. The aim of this work was toelucidate the effect of a standardized pomegranate extract during four months of supplementationin elderly mice [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2048,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2047","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/posts\/2047"}],"collection":[{"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/comments?post=2047"}],"version-history":[{"count":1,"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/posts\/2047\/revisions"}],"predecessor-version":[{"id":2050,"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/posts\/2047\/revisions\/2050"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/media\/2048"}],"wp:attachment":[{"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/media?parent=2047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/categories?post=2047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.medikors.com\/eng\/wp-json\/wp\/v2\/tags?post=2047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}